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a-Tocopheryl Succinate

Catalog No. : DI-T-62141
CAS Number : 4345-03-3
Molecular Weight : 530.78
Molecular Formula : C33H54O5
Synonym : CV 104; Covitol 1210; NSC 173849; d-a-Tocopherol Acid Succinate; Butanedioic Acid 1-[(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] Ester; (+)-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol Hydrogen Succinate; d-a-Tocopheryl Acid Succinate; (+)-a-Tocopheryl Succinate; Succinic Acid (+)-mono[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl] ester; a-Vitamin E Succinate; Vitamin E d-a-Tocosuccinate;
Application Notes : A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.
References :Weber, T. et al.: Clin. Can Res., 8, 863 (2002);Staphelberg, M. et al.: Biochem. Biophys. Res. Comm., 318, 636 (2004); Ramathapuram, L.V. et al.: Cancer Immunol. Immununother., 55, 166 (2005);